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Besides, ACSL1 is recently found essential for -eleostearic acid (ESA) induced ferroptosis

Cancer Lett 383:282294 Lamonte G, Tang X, Chen JL et al (2013) Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress

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Having two distinct methods (i.e., the GNPT-coatomer interaction and the LYSET-GOLPH3 interaction) for recycling GNPT at the Golgi and a third to retrieve any escaped enzyme ensures the robustness of the M6P pathway, minimizing the risk of its compromise

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It also shows the importance of maintaining and restoring the homeostasis of intestinal microbiota, decreasing inflammatory state and maintaining the integrity of intestinal and bloodbrain barriers