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We propose that chronic exposure to a particular suite of environmental and genetic factors elicits a trajectory of impaired mitochondrial biology that maximally impacts subsets of mitotypes abundant in the substantia nigra, striatum, and cerebral cortex, which eventually surfaces as the hallmark features of PD

Pancreatic -cells are highly vulnerable to oxidative stress due to their relatively low antioxidant defense system and high endogenous production of reactive oxygen species (ROS) (125, 126)

The addition of NAC to pirfenidone did not significantly affect the safety and tolerability profile of pirfenidone, but it did not appear to confer further benefits in terms of forced vital capacity, although it must be acknowledged that the study was underpowered to demonstrate a meaningful difference

Some of the symptoms, especially early on, can be vague

Autophagosome maturation and fusion

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