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It has not been associated with significant immunosuppressive effects, instead demonstrating immunomodulatory activity by reducing pro-inflammatory cytokines like IL-6 and TNF-, without impairing normal immune function

aureus with eugenol led to increased production of reactive oxygen species (ROS), hyperactivation of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, and catalase, ultimately resulting in oxidative stress-induced cell death (Bai et al., 2023)

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Metal ions, being toxic to the nervous system and causing oxidative stress, have been reported to participate in the pathogenesis of AD [123]

It has been demonstrated that ferroptosis inhibitors, such as ferrostatin-1 (Fer-1) and lipostatin-1, lower lipid peroxidation and arrest macrophage death