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This change remodels the immune microenvironment, recruiting and activating more CD8 + T cells

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Notably, TMAO also amplifies ERS markers such as heat shock protein 60 and glucose regulated protein 78kD in macrophages, correlating with elevated toll-like receptor 4 expression and proinflammatory cytokine production (e.g., TNF-, IL-6) (88, 89)

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