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These findings lead us to hypothesize that the reduction in TGF-1 secretion by ECs, which subsequently affects CFs, may be the primary mechanism underlying the PD-1 inhibitor-induced decrease in cardiac interstitial collagen

Females have been shown to give a 1.5- to 1.7-fold higher risk factor for having adverse drug reactions than men 75

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"These alterations in the microbiota influence stress-related behaviors" (Foster, 2013)

The lipid bilayer, which is rich in PUFAs, ensures membrane fluidity, which is essential for sperm motility and the ability to undergo capacitation and the acrosome reactiontwo key processes required for successful fertilization

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