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Sterile water reconstitutions, without a preservative, are much shorter-lived and are usually treated as single-use

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Animal studies exploring the direct effects of vitamin B12 on COX enzyme are lacking

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One major hurdle that thyroid patients face when it comes to B12 deficiency is that it can be very difficult to differentiate between true hypothyroid symptoms, meaning those caused by low thyroid function, and symptoms related to low B12 levels in the serum and in the cells