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The authors describe cases where the only visible symptoms were persistent, non-itchy hyperpigmented patches or polymorphic skin lesions

Although theres a small amount of evidence to support the use of chanca piedra for kidney stones in humans, larger and more rigorous human studies are needed to determine if chanca piedra truly has any benefits

Intrinsic mechanisms mainly involve enzymatic processes [19], including antioxidant enzymes such as superoxide dismutase (SOD), peroxidases, and glutathione reductase (GR)
Diabetes, in turn, promotes inflammation and may increase B6 demand
RF and EP contributed with clinical measurements
