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Glutamatergic theories of schizophrenia are based on the ability of N-methyl-D-aspartate receptor (NMDAR) antagonists to induce schizophrenia-like symptoms, as well as emergent literature documenting disturbances of NMDAR-related gene expression and metabolic pathways in schizophrenia

Increased dietary intake, decreased leptin level, and high affinity to histamine (H1) receptors [158], especially by TCAs such as imipramine-type antidepressants, may be responsible for the underlying mechanisms

doi: 10.1016/j.bbr.2014.09.005

It can have both a negative effect, such as HFD inducing metabolic endotoxemia, or a positive effect, such as a diet rich in plant polyphenols or fermented dairy products, increasing the expression of TJ proteins and promoting the development of beneficial bacteria
Biophysica Acta 47 , 184185 (1961)

Representative images of immunohistochemistry (IHC) of Hmgcs2 on sections from 24 h fasted WT or eIF4E S209A livers