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A range of compounds emitted by CAFs, such as vascular endothelial growth factor A (VEGF-A), is noted to play a role in the stimulation and sustenance of T regulatory (Treg) cells, either directly or indirectly [46]

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In fact, long-term dependence can: Mask underlying dysfunctions Delay proper rehabilitation As clinicians, we need to shift the conversation from suppression to correction

Be prepared to discuss developmental history in detail, including early milestones, school experiences, social relationships, and family history of similar conditions

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