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These mechanisms link oxysterols to cholinergic deficits seen in neurodegenerative conditions like AD

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G., Leeuwenburgh, C., & Mattson, M

Chemical characterization of urate hydroperoxide, a pro-oxidant intermediate generated by urate oxidation in inflammatory and photoinduced processes

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This bidirectional behavior highlights a critical context dependence in antioxidant biology, where the same metabolite may either suppress or amplify ferroptotic stress depending on iron availability and intracellular redox flux