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Furthermore, free radicals are known to oxidize the extracellular sites of glutamatergic N -methyl-d-aspartate receptors, leading to attenuation of LTP and synaptic neurotransmission (Haxaire et al., 2012

Gene expression analysis further demonstrated a significant upregulation of nerve growth factor (NGF) and a downregulation of brain Tyrosine Kinase Receptor A (TrkA) in individuals with diabetic neuropathy compared to healthy controls

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Despite persistent mechanistic links between ferroptosis and PD, translational research exploring Exos-based therapies to target ferroptosis remains in its early stages

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