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Also, IGF1 expression is significantly reduced in ATG7 knockout mice, indicating that IGF1 plays a beneficial role in regulating autophagy (Zecchini et al., 2019)

854 Changes associated with ferroptosis in the cartilage of the injured articular area in OA patients, including GPX4 downregulation, ACSL4 upregulation, MDA accumulation, and mitochondrial morphological and function changes, are more severe than in the intact articular area and worsen with OA progression

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Intracellular Distribution and Functions of GSH Within the cell, there are three main glutathione pools