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Thus, further studies on a diverse set of in silico, in vitro, and in vivo animal models are required and standardization of the pathognomic behavioral assay in order to establish pathogenic hotspot of disease and to evaluate the novel dietary/metabolic therapy that can provide insight into the neurobiology of ASD is warranted

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Using the 6-OHDA rat model of PD, it has been demonstrated that systemic administration of Deferasirox (20 mg/kg), Deferiprone (10 mg/kg), or DFO (30 mg/kg), significantly prevented the decrease in dopaminergic neurons and striatal dopamine levels

97,127 The underlying mechanisms involved in macrophage replenishment during different pathophysiological processes are not identical