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This is a similar mechanism to methylene blue, another targeted rescue therapy for vasoplegic shock, which acts as a competitive antagonist of NO to inhibit its vasodilatory effects [14]

Caution is advised for individuals with specific health conditions, like asthma

Table 2 summarizes some of the current FDA-approved CNS nasal products

While small-scale studies are ongoing, the transition to adequately powered trials with comparison groups remains a research priority for advancing regulatory policy and understanding

Upon activation by toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE), macrophages initiate the synthesis of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and other inflammatory biomarkers, resulting in further hepatic injury (Guilliams and Scott 2022)

Notably, iron rich status promotes M2-like macrophage phenotype and negatively regulates M1 pro-inflammatory response [65]