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Pyruvate kinase (PK) is the most common enzymopathic cause of chronic hemolysis, followed by glucose phosphate isomerase deficiency (GPI), and pyrimidine 5 nucleotidase-1 (P5N1), which is essential for removal of toxic nucleotide precursors

Rohrl C, Stangl H

Preserved protein synthesis in the heart in response to acute fasting and chronic food restriction despite reductions in liver and skeletal muscle

Furthermore, there also appears to be a link between the severity of obstructive sleep apnea and the reduced native GLP-1 response, which further deteriorates glucose metabolism, causes weight gain, and increases the risk of developing type 2 diabetes

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Pujiastuti et al., 2019