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Inflammation in the vascular bed: Importance of vitamin C

2023;22:e13828

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[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Caccialanza R., Laviano A., Lobascio F., Montagna E., Bruno R., Ludovisi S., Corsico A.G., Di Sabatino A., Belliato M., Calvi M., et al

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Similarly, macrophage polarization exemplifies regulated immunometabolism: pro-inflammatory M1 macrophages exhibit high glycolytic activity to support iNOS-mediated NO production, whereas anti-inflammatory M2 macrophages depend on oxidative phosphorylation for tissue repair functions ( 2.1.3.2 Mitochondrial respiratory dysfunction and ROS overload In trauma and major surgery, studies of circulating leukocytes ( e.g