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Because of impaired endothelial barrier function, there is an imbalance in released vasodilatory substances (such as NO, angiotensin II, thromboxane A2), further exacerbating vascular constriction

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Given the reversibility of epigenetic modifications, there is an opportunity to develop targeted therapies that can modify the cancer epigenome and overcome drug resistance

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Conversely, the opposite effect is observed during the deletion of the cPLA2 gene [60], and inhibition of the cPLA2 isoform in murine keratinocytes (PAM212) suppresses cell proliferation and migration [58]

A 860-g filtration was performed for 2 min on the white turbid fluid