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IGF-1 LR3 has been investigated in preclinical studies for its potential role in supporting tendon and ligament repair, as IGF-1 promotes cell proliferation, collagen synthesis, and tissue regeneration

VIC can neutralize reactive oxygen species (ROS) produced during normal metabolism, thereby preventing oxidative stress and cellular damage [2,6]

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Beyond macrophages and neutrophils, other immune cells such as dendritic cells and T and B lymphocytes may also participate in ferroptosis-related immune regulation in periodontitis, collectively forming a multilayered and interconnected immune-ferroptosis network

10.1186/s13062-023-00387-5 Biol
