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These findings indicate that the therapy restored both muscle structure and function

It is classified as an unapproved new drug , meaning it cannot be legally marketed, sold, or prescribed as a therapeutic agent

Foundational Discovery Selective Senolytic Elimination in Aged Mice (Cell, 2017 Baar et al.) FOXO4-DRI Restores Fitness, Fur Density, Renal and Liver Function in Aged Mice The foundational study introducing FOXO4-DRI as a senolytic peptide was published in Cell by Baar and colleagues in 2017
An altered chromatin function in response to a low niacin status may have far reaching consequences that can affect genomic stability, cell division, differentiation and apoptosis

Although still in early development, this approach has shown promise for targeting various organ systems

Ann Rheum Dis (2023) 110
