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Selective iron chelation in Friedreich ataxia: biologic and clinical implications

DOI: 1560-8530/2005/07-5-768-772 70

The authors thank the So Paulo Research Foundation FAPESP (Grants #2017/07351-4 and #2023/11496-9) and National Council for Scientific and Technological Development CNPq (Grant #409498/2021-1) for funding the study

FIGURE 1 8 Mitochondrial shuttles contribute to cellular redox homeostasis The G3PS (Figure 2A) and MAS (Figure 2B) are responsible for shuttling cytoplasmic NADH reducing equivalents to mitochondria for oxidation

Early observations suggest that it may interact with signaling pathways involved in maintaining cellular structure and function in preclinical models