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Tumor heterogeneity, characterized by the presence of multiple clones, increases the likelihood of drug-resistant clones, resulting in treatment failure or recurrence

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Patented: see www.takeda.com/en-us/patents Revised: 3/2025 ADV372 ADVATE [Antihemophilic Factor (Recombinant)] NDC 0944-3051-02 Single-dose only For Intravenous Administration Only Rx Only Lyophilized powder for reconstitution ADVATE and diluent preassembled in BAXJECT III system Product does not contain plasma/albumin ACTUAL POTENCY 2 mL Takeda ADVATE [Antihemophilic Factor (Recombinant)] NDC 0944-3051-03 For Intravenous Administration Only ADVATE and diluent preassembled in BAXJECT III system Do not open until time of use Do not use if packaging is opened or damaged Discard unused portion