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Outer surface protein C (OspC) is thought to be an important virulence factor involved in the transmission and establishment of early infection (51, 52)

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Hepatology 2002;35(5):1093103

This structural transition leads to a separation of the ICD, at least to the Box1Box2 motif, and dissociates the JAK2 kinase-pseudokinase trans interaction and brings the KDs in proximity allowing trans phosphorylation and activation (1, 51)

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