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240 It has also been shown that MTA accumulation and secretion occur in MTAP-deficient GBM, but no significant MTA accumulation was detected in vivo because the stromal cells in the TME express WTAP and consume the MTA emitted by tumor cells and increase the activity of PRMT5

Therefore, to prevent a significant shift in the redox equilibrium, GSSG can either be actively exported out of the cell or react with a protein sulfhydryl group, which leads to the formation of a mixed disulfide