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Consequently, increasing the activity of phase II enzymes, such as glutathione S-transferases (GSTs) and NQO-1, may help prevent cancer by enhancing the elimination of potential carcinogens (see the Nrf2-dependent antioxidant pathway) (63)

On the other hand, oxidative stress in regulatory T cells strengthen their suppressor activity, and administration of an NRF2-inducing reagent sulforaphane inhibits tumor growth in allograft experiment (Maj et al

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Developmental Pb 2+ exposure has also been linked to increased apoptosis, particularly during critical periods of brain formation, contributing to long-term neurodevelopmental abnormalities in both mammalian and zebrafish models [75]

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NTBI, Non-Transferrin-Bound Iron
