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These nanoparticles mitigate spatial barriers and improve cellular uptake, thereby inducing cuproptosis and ICD [324]

Hayes JD, Pulford DJ (1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

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These results suggested that GGT was the most important enzyme responsible for GSH degradation and that deletion of both ggt and pepT could significantly suppress the GSH degradation