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Acta 839, 6270

Saltelli A, Tarantola S, Campolongo F, et al

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elegans [125], which may have implications for understanding the progression of Parkinson's Disease

Even if intermittent dosing of rapamycin extends the lifespan of mice and has a milder impact on glucose homeostasis compared to continuous administration, without triggering the glucose intolerance, 411 a long-term administration of rapamycin eventually inhibits not only mTORC1 but also mTORC2 and may lead to hepatic insulin resistance
