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To further elucidate the pathophysiological role of mitochondrial dysfunction and inform treatment development, future studies should integrate omics-based profiling with dynamic neuroimaging to map the spatiotemporal relationship between mitochondrial imbalance and affective symptoms

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Glucagon-like peptide-1 receptor (GLP-1R) agonist NLY01 prevents the generation of reactivity in astrocytes and protects neurons from cell death 152