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Inflammation: The Common Pathway of Stress-Related Diseases

[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Filomeni G, Aquilano K, Civitareale, et al

Without offering a citation for a published paper or sharing any data, Sikirics 2025 review states that this clinical trial found that the drug was safe and well-tolerated in humans

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More generally, potentially pathological changes to the NO nitrergic co-transmission system have been reported to correlate with a range of additional psychiatric conditions, including other anxiety disorders, depression, and bipolar disorder (Dhir and Kulkarni, 2011

257 , 301 On the other hand, synthetic products exhibit drawbacks including but not limited to high expense, instability, and potential immunogenicity