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10 Environmental Exposures Epidemiologic studies and animal experimental models have identified an association between PD and the following environmental risk factors: rural residence, farming, well-water drinking, exposure to pesticides (including organochlorines, carbamates, paraquat, maneb, rotenone, and diethyldithiocarbamate), and long-term occupational exposure to copper, iron, lead, and manganese

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In addition to detoxifying exogenous aldehydes, ALDH2 serves a key role in eliminating endogenous aldehydes generated during oxidative stress, including 4-hydroxy-2-nonenal (4-HNE), malondialdehyde (MDA) and acrolein (29,30)

An epidemic of DM is underway as result of population growth and aging, increased urbanization, prevalence of obesity and sedentary lifestyle [1]

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