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Ferroptosis is stimulated by the formation of ROS after RAS-selective lethal 3 (RSL3), a ferroptosis inducer, that binds to and deactivates GPX4 [46, 48]

1.11.1.6) is a tetrameric ferriheme oxidoreductase, which catalyzes H 2 O 2 dismutation to water and gaseous oxygen, as shown in reaction 3 ( CAT is mainly located in peroxisomes, and despite being ubiquitous, the highest activity is present in liver and red blood cells

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10.1186/s12943-024-02215-4 100 LiY.ChenC.JiX.JiangN.WangF.GaoX.et al (2025b)

They proposed that PGK facilitates the cleavage of Cys512Cys536 disulfide bond of plasmin by hydroxyl anion ( OH) and results in the formation of sulfenic acid at Cys512 along with a Cys536 thiolate thus presenting an opportunity for disulfide rearrangement

Oral CIT supplementation (5.6 g daily) for 1 week significantly reduced baPWV by ~0.14 m/s in middle-aged men with high baseline baPWV [27]