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10.1523/JNEUROSCI.0964-17.2017 J
Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma
Oxidative stress response and nrf2 signaling in aging
In addition, increased ganglioside GM3(GM3) in the renal cortex during the early stages of diabetes alters pro-survival receptor-related Automatic Kernel Tunables (Akt) and Protein kinase B signaling to exacerbate DKD (6568)
van Hoppe S, Rood JJM, Buil L, Wagenaar E, Sparidans RW, Beijnen JH, Schinkel AH (2018) P -glycoprotein (MDR1/ABCB1) restricts brain penetration of the Brutons tyrosine kinase inhibitor ibrutinib, while cytochrome P450-3A (CYP3A) limits its oral bioavailability
