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Animal studies provide mechanistic insights

By employing short hairpin RNA (shRNA) to stably knock down HIF-1 expression, they observed significant reductions in the growth of glioma xenografts in immunodeficient mice (212)

Tse, 2010)

The diet was restricted such that no vitamin C containing products were consumed for at least 24 h prior to administration of the investigational products until all blood draws were completed

Annexin V/propidium iodide staining confirmed an increase in apoptosis, and real-time PCR demonstrated reduced mitochondrial cytochrome C mRNA levels [30], suggesting activation of the intrinsic apoptotic pathway

The treatments are not the same