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The crimp seal is applied at the end of the manufacturing process and provides visual verification that the vial has not been previously opened

Am J Cancer Res 14(5):23262342 Li Y et al (2024b) Advancements in mitochondrial-targeted nanotherapeutics: overcoming biological obstacles and optimizing drug delivery

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Reprogramming tumor-associated macrophages by nanoparticle-based reactive oxygen species photogeneration

Higher doses can produce more serious, potentially life-threatening effects (Figure 3)

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