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Description

P62 can bind light chain 3 (LC3)-labeled autophagosomes to substrates, promote the combination of substrates and autophagosomes, and promote the occurrence of autophagy

Medical comorbidities in autism: challenges to diagnosis and treatment

Ferroptosis is an iron-dependent regulated necrosis that is considered a byproduct of cellular metabolism because of its close association with oxygen, iron, and lipid metabolism (116), it is dependent on the metabolites reactive oxygen species (ROS), phospholipids containing polyunsaturated fatty acid chains (PUFA-PL), and the transition metal iron, and exhibits biochemical features of iron accumulation and unrestricted lipid peroxidation, as well as morphologic alterations such as loss of plasma membrane integrity, mitochondrial abnormalities, cytoplasmic swelling, and moderate chromatin condensation (117, 118)

Mass spectrometry To obtain whole cell samples for the MS analysis (Figs

Lastly, although the hangover symptom surveys (AHS and AHSS) showed no significant differences between the GSH and placebo groups overall, the subjective nature of these surveys may have influenced the results