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Here, in two clinical trials, the authors show that ImmTOR, previously reported to reduce drug immunogenicity in animal studies, helps mitigate ADA induced by pegylated uricase for treating patients with hyperuricemia.

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Addition of 2 mM PPG resulted in the decrease of the intracellular taurine levels: from 10.25 5.00 observed in control, to 2.53 0.68 nmol/mg protein (24 h of culture) and from 17.06 9.40 to 2.43 0.26 nmol/mg protein (control vs

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