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Altered concentrations of TCA cycle intermediates, including -ketoglutarate (-KG), succinate, fumarate, and acetyl-CoA metabolites, impact histone demethylases and enzymes catalyzing hydroxylation and demethylation processes, to thereby shape the cancer epigenetic landscape [76]

doi: 10.1158/2159-8290.CD-21-0900 88

The Research Profile section below details the mechanisms and the literature that frames each

Upon TNF stimulation, NF-B and MAPK pathways are activated to promote the transcription of proinflammatory and pro-survival genes 43

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