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Thus, various tumors, including glioma, secondary glioblastoma, and acute myeloid leukemia (AML), harboring heterozygous point mutations in the active sites of IDH1/2 show dramatic increases in the R-2-HG levels 111,113,114,115

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[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Andersson S, Russell DW

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