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From a research perspective, it is important to persevere in investigating the specific cellular and molecular mechanisms of action of various plant bioactive metabolites, as this may provide new perspectives to understand their potential efficacy

Excessive ROS (1000 M H 2 O 2 [57], 100 M H 2 O 2 [58]) is reported to induce mutations of nuclear [59] and mitochondrial DNA [60], affecting the replication, proteins post-translation modifications [61], and membrane phospholipids [60] in the cardiac cells, accelerating aging and cell death [62]

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Extracellular glutathione peroxidase GPx3 and its role in cancer

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One molecule that has received a lot of attention in the islet field in recent decades is thioredoxin-interacting protein (TXNIP), as it was identified as the gene with the largest increase in expression in human islets exposed to high (20 mM) glucose (58)