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Catecholamine influences and sympathetic neural modulation of immune responsiveness

Although oral therapy with the least toxic of these compounds, glutathione monoethyl ester, did raise erythrocyte and white blood cell glutathione levels in a few affected patients (W Rhead, unpublished results), it also provoked moderate gastrointestinal irritation resulting in vomiting and diarrhea, largely precluding oral therapy with this compound or other related molecules containing free sulfhydryls

Glutathione (-glutamyl-cysteinylglycine) with the molecular formula: C10H17N3O6S, is a small, low molecular weight, water-soluble thiol tripeptide consisting of three amino acids (glutamate, cysteine and glycine)

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The NL4-3 derived p6*-PR contains two natural autoproteolysis sites: the proximal (P) site, located between p6* and PR, which is essential for the liberation of mature PR, and the distal (D) site at the N-terminal region of p6*
