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The transmembrane rather than paracellular transport of lipophilic compounds was supported by the demonstration of an inverse association between lipid/water partition coefficient and increased transport rate following calcium chelation, i.e., disrupting intercellular junctions increased the transport of hydrophilic but not of lipophilic small organic molecules [31]

Discoloration changes indicate degradation: Cloudiness = peptide precipitation or contamination Green or pink discoloration = copper reduction (Cu Cu) Colorless = complete copper dissociation Reconstituted solutions should be stored at 28 C

Du K, Ramachandran A, McGill MR, Mansouri A, Asselah T, Farhood A, Woolbright BL, Ding WX, Jaeschke H

Orthoesters are versatile acid-labile linkers for antibody-drug conjugates

DAngelo, S