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No participants withdrew from any trial due to tolerability issues, indicating that even when side effects occurred, they were sufficiently manageable that participants chose to continue treatment

Chapter 11: Presenting results and Summary of findings' tables

Valentino, M A et al

Its ability to interact with lipolytic pathways without the confounding growth-promoting effects of full GH makes it particularly useful for dissecting the metabolic arm of GH signalling in laboratory models

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It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile