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Poly-ubiquitin chains are particularly important, as they often label target proteins to be sent to the proteasome for degradation, which is a major mechanism by which cells remove unwanted or damaged proteins

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA: Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria

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The lysate was cleared by centrifugation and the protein was purified by Ni-His-affinity chromatography in batch mode

Lou C, Wu K, Shi J, Dai Z, Xu Q

They reduce the oxidative stress that triggers excess melanin production