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The molecular interaction analysis further highlighted the significance of Tyr-326 in aromatic interactions, along with the presence of a critical hydrogen bond with Cys-172, essential for anchoring MAO-B inhibitors

This is due to low absorption in the intestine, and breakdown by enzyme activity

Carney CE, Buysse DJ, Ancoli-Israel S, Edinger JD, Krystal AD, Lichstein KL, et al

Naaijen J, Bralten J, Poelmans G, et al

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