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196 GDF15 further promotes fatty acid oxidation and lipid metabolism in skeletal muscle and adipose tissue, facilitating beneficial weight loss and glycemic improvements

Abbreviations 4E-BP1: Eukaryotic translation initiation factor 4E-binding protein-1 6W: Six-minute walk test AEs: Adverse events BMI: Body mass index Comp: Composite endpoint DXA: Dual-energy X-ray absorptiometry ITT: Intent-to-treat LS: Lower strength MM: Muscle mass mTOR: Mammalian target of rapamycin MuRF1: Muscle RING-finger protein-1 NNHPD: Natural and non-prescription health products directorate NSAID: Non-steroidal anti-inflammatory drug PP: Per-protocol QoL: Quality of life S6K: p70-S6 kinase UPS: Ubiquitinproteasome system US: Upper strength References Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, Abellan Van KG, Andrieu S, Bauer J, Breuille D, Cederholm T, Chandler J, De MC, Donini L, Harris T, Kannt A, Keime GF, Onder G, Papanicolaou D, Rolland Y, Rooks D, Sieber C, Souhami E, Verlaan S, Zamboni M

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Moon, T

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Metal Ion Balance : The dipeptide functions as a natural metal-binding compound, helping maintain healthy copper and zinc balance within normal ranges to support optimal cellular function