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As levels fall, the body becomes more vulnerable to oxidative stress

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Apart from the accessibility of IONP to infected macrophages (limited in the cutaneous lesions) either after parenteral or local administration, a questionable issue is the targeting of macrophages as an immunomodulatory approach for the treatment of leishmaniasis versus other immune cells

Upon activation, DRP1 undergoes conformational changes facilitated by interactions with other DRP1 molecules within the same mitochondrion, forming ring-shaped or helical aggregates that divide the intermembrane space between the inner and outer mitochondrial membranes [56]

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