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Transcription factors with the most connections to other genes included EPAS1 (also known as HIF-2), KLF13, TAL1, TBX3, GATA2, and BCL11A (Additional file 4)

Unlike dense BG synthesised by the melt-quench technique, most MBGs do not require Na 2 O to lower the melting temperature 18

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To further confirm the functional significance of interface I, we mutated the residues Lys47, Lys91, Phe112, and His114 in the N domain of HGF to either glutamate or alanine

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One potential candidate IC for cancer patients is IL-2-anti-IL-2 complex (IL-2 IC), which could extend IL-2 bioactivity from hours to days