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Description
Based on the modeled PDZD-8 structure, we hypothesized that changing leucine-98 and isoleucine-252 of the PDZD-8 SMP domain to tryptophan (W) would block lipid insertion into its hydrophobic groove (Supplementary Fig
Yan M, Cai WB, Hua T, Cheng Q, Ai D, Jiang HF, et al
In both conformations, E220 is engaged in an ionic interaction with R169 (TM3) that, in turn, coordinates D165 (TM2)
J Clin Investig
78 (Pt 7), 15271531
10.1002/gps.4196 2
