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It was Coco Channel who first made tanning fashionable
The lesion is asymmetric and there is also asymmetry in the distribution of color that is variegated and shows dark-brown specks against a tan background
New Engl J Med 1989
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Farbers pioneering use of antifolate drugs established cancer chemotherapy, and another folate antagonist, methotrexate, remains a key component of childhood acute lymphoblastic leukemia (ALL) treatment, with a cure rate of up to 90% when combined with l-asparaginase
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