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Mutant OPTN promotes the expression of downstream target genes of NF-B, such as p53 and proapoptotic proteins, to induce cell death by triggering p53-dependent apoptosis

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Zhao, D., Liang, Y., Dai, S., Hou, S., Liu, Z., Liu, M., Dong, X., Zhan, Y., Tian, Z., & Yang, Y