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Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

Hay and other feed may not contain high levels of components essential for equine health, so supplementation helps fill these nutritional gaps

For example, those with severe deficiencies might need 1,000 mcg weekly, while others might only need 100 mcg monthly

Hill MH, Flatley JE, Barker ME, et al

Deficiency in vitamin B12 can lead to the accumulation of methylmalonyl-CoA, which is subsequently converted to methylmalonic acid (MMA) (, , )